Other Name(s):Alfa-GPC, Alpha Glycerol Phosphoryl Choline, Alpha-Glyceryl Phosphoryl Choline, Alpha-Glyceryl Phosphatidylcholine, Alpha-glycerylphosphorylcholine, Choline alphoscerate, Glycerophosphorylcholine, Glycérophosphorylcholine, GPC, GroPCho, L-A-Glyceryl Phosphorylcholine, L-alpha-glycerylphosphorylcholine.

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Alpha-GPC is a chemical released when a fatty acid found in soy và other plants breaks down. It is used as medicine.

In Europe alpha-GPC is a prescription medication for the treatment of Alzheimer"s disease. It is available in two forms; one is taken by mouth, và the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to lớn improve memory.

Other uses for alpha-GPC include treatment of various kinds of dementia, stroke, & “mini-stroke” (transient ischemic attack, TIA). Alpha-GPC is also used for improving memory, thinking skills, and learning.

How does it work?

Alpha-GPC seems to increase a chemical in the brain called acetylcholine. This brain chemical is important for memory & learning functions.


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Insufficient Evidence khổng lồ Rate Effectiveness for...

Alzheimer's disease. Developing research suggests that taking 1200 mg of alpha-GPC per day significantly improves thinking skills in Alzheimer's patients after 3 to lớn 6 months of treatment.Dementia. Giving 1000 mg of alpha-GPC per day as a shot might improve symptoms of vascular (multi-infarct) dementia including behavior, mood, and thinking skills. Researchers who did this study used a prescription-only form of alpha-GPC (Delecit) that is not available in the US.Stroke & “mini-stroke” (transient ischemic attack, TIA). Stroke & TIA patients who receive alpha-GPC within 10 days after the stroke or TIA seem to have a better recovery. Early research suggests that people who get 1200 mg of alpha-GPC per day as a shot for 28 days, followed by 400 mg of alpha-GPC three times daily (1200 mg/day) by mouth for 6 months, recover more thinking skills & are better able lớn function.Improving memory.Thinking skills.Learning.Other conditions.More evidence is needed to lớn rate the effectiveness of alpha-GPC for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according khổng lồ the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to lớn Rate (detailed description of each of the ratings).


Alpha-GPC seems to be safe when used appropriately. It can cause side effects in some people including heartburn, headache, insomnia, dizziness, skin rash, & confusion.

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QUESTION Next to lớn red peppers, you can get the most vitamin C from ________________. See Answer
Pregnancy and breast-feeding: Not enough is known about the use of alpha-GPC during pregnancy & breast-feeding. Stay on the safe side và avoid use.


Scopolamine (Transderm Scop)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.

Alpha-GPC increases a chemical in the brain called acetylcholine. Scopolamine blocks this same chemical. But it"s not known if alpha-GPC decreases the benefits of scopolamine.


The appropriate dose of alpha-GPC depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information lớn determine an appropriate range of doses for alpha-GPC. Keep in mind that natural products are not always necessarily safe và dosages can be important. Be sure to lớn follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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Report Problems to lớn the Food and Drug Administration

You are encouraged khổng lồ report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. View abstract.

Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7. View abstract.

Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to lớn the evaluate the efficacy & tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41. View abstract.

Gatti G, Barzaghi N, Acuto G, et al. A comparative study of miễn phí plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine & citocholine in normal volunteers. Int J Clin Pharmacol Ther Toxicol 1992;30:331-5. View abstract.

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Moreno MDM. Cognitive improvement in mild to moderate Alzheimer"s dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial. Clin Ther 2003;25:178-93. View abstract.